Wednesday, April 26, 2017

Are We Missing Something?


"The Scientist" 


This weekend will be the Inaugural Institute of Cannabis Research (ICR) at Colorado State University-Pueblo, this international, multidisciplinary cannabis research conference set for April 28-30th 2017, on the Colorado State University-Pueblo campus.  The keynote address on Saturday will be presented by none other than, “The Scientist”, Raphael Mechoulam, Ph.D., who is considered “the father of cannabis research.”

The ICR conference will celebrate a myriad of research and intellectual pursuits from internationally renowned speakers and pioneering cannabis scholars. The preliminary program provides information on more than 70 scheduled presentations from 100+ state, national, and international cannabis researchers from private research organizations, prominent universities, state and national government agencies, and industry representatives.

Dr. Mechoulam is a pioneer in the field of cannabis research and a discoverer of the endocannabinoid system. Dr. Mechoulam’s keynote address at the ICR conference is titled: The Endocannabinioid System: A Look Back and Ahead. Raphael Mechoulam, Ph.D., who is considered “the father of cannabis research,” will present the inaugural Mechoulam Lecture, which will commemorate the groundbreaking discoveries that have made contemporary cannabis science possible. Dr. Mechoulam is professor in the Department of Medicinal Chemistry at the Institute of Drug Research at Hebrew University in Israel.
Dr. Mechoulam is an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel. He was among the first to complete the total synthesis of the major plant cannabinoids Δ9-tetrahydrocannabinol, cannabidiol, cannabigerol, and others. Dr. Mechoulam also played a key role in the isolation of the first described endocannabinoid anandamide.
Prof. Mechoulam received his Masters Degree in Biochemistry from the Hebrew University in 1952 and his Ph.D. from the Weizmann Institute in 1958 where he studied under Professor F. Sondheimer. He completed his postdoctoral research at the Rockefeller Institute. Dr. Mechoulam is currently with the Institute for Drug Research at the Faculty of Medicine at the Hebrew University in Jerusalem. He is former Rector of the University and is a member of the Israel Academy of Sciences.
Dr. Mechoulam has received many honours, including honorary doctorates from Spain and USA, the Israel Prize in 2000 and the European College of Neuropsychopharmacology Lifetime Achievement Award in 2006. In 2012, he received the Rothschild Prize. His research interests are in the field of the chemistry and biological activity of natural products and medicinal agents. His main contributions are in the field of the constituents of cannabis and the endogenous cannabinoids found in the brain and the periphery. He has published extensively on their pharmacological activities.



About The Documentary, “The Scientist”, His Life And Work
In 1964 Professor Raphael Mechoulam was on a public bus carrying 5 kilos of premium Lebanese hashish in a plastic bag to his laboratory at the Weitzmann Institute in Rehovot. That noticeably fragrant bus ride turned out to be a fateful one, as Mechoulam used his haul to discover the psychoactive component in Cannabis, Tetrahydrocannabinol (THC). It was a discovery that had eluded scientists for decades. Twenty years later, Mechoulam ascertained that THC interacts with the largest receptor system in the human body, the endocannabinoid system (ECS). He then found that the human brain produces its very own cannabis—a chemical that they named anandamide after the Sanskrit word ananda, “bliss.”

Though still unknown to most researchers and medical professionals because of the worldwide prohibition of marijuana, the importance of the endocannabinoid system is growing daily. It has been called the “supercomputer that regulates homeostasis in the human body.” Because receptors are found throughout the brain and in every major organ, this system is thought to be involved in most disease state. This is one reason that cannabis treats so many different illnesses. Mechoulam has been investigating this compound longer and more thoughtfully than any other scientist. He has unearthed cannabis’s role in treating seizure disorders, schizophrenia and PTSD, as well as on other functions that govern human health like infant-maternal bonding. He has been awarded numerous scientific prizes and is universally acknowledged as the “father of cannabinoid medicine.” Despite these accolades, Mechoulam’s name isn’t known outside of a small group of researchers.
“The Scientist is a documentary that traces the story of Mechoulam from his early days as a child of the Holocaust in Bulgaria, through his immigration to Israel, and his career as the chief investigator into the chemistry and biology of the world’s most misunderstood plant.
“When Darwin finished his ideas on evolution he put them in a drawer for 20 years because he feared what the Church would say,” says Zach Klein, the writer, producer, editor of The Scientist. “Mechoulam was never vilified because he is such a great scientist, but the world has been slow to understand his findings because of the demonization that cannabis suffered since the beginning of the war on drugs.”
Klein first met Professor Mechoulam when researching the ways Cannabis reduces the symptoms of chemotherapy that his mother was experiencing while being treated for breast cancer. That led to his first documentary, Prescribed Grass, which aired on Israeli television in 2009 and prompted health officials in that country to launch what is today the world’s largest state-sponsored medical marijuana program. (Per EurpoaWire on July 31, 2015)

The Facebook Event Page, is hosted by Pueblo Cannabis Society, The Pueblo Cannabis Society is a new, Pueblo-based discussion group that will monitor the social impacts of legal cannabis on Pueblo (CO) and its citizens.
Find Event Tickets Here.
Some of the World–Renowned International Prizes Awarded to Dr. Raphael Mechoulam:

- Somach Sachs Prize for “best research by a scientist below 35 at the Weizmann Institute”, 1964.
- Distinguished Visiting Professorship, Ohio State University, Columbus, Ohio, 1982-1983.
- “Pharmacology, Biochemistry and Behavior” Nov. 1991 issue dedicated to R.Mechoulam. for achievements in the cannabinoid field.
- Elected, Member Israel Academy of Sciences, 1994.
- David R. Bloom Prize, 1998, for “excellence in pharmaceutical research”, Hebrew University.
- The International Cannabinoid Research Society (ICRS) establishes an annual award to be named The R. Mechoulam Annual Award in Cannabinoid Research, 1999.
- Israel Prize in Exact Sciences – chemistry, 2000.
- Ariens Award and Lecture. 2000. Dutch Pharmacological Society sponsored by Solvay Pharmaceuticals. Amsterdam.
- Doctor Honoris Causa, Ohio State University, Columbus, Ohio, 2001.
- Elected, Honorary Member, Israel Society of Physiology and Pharmacology, 2002.
- Heinrich Wieland Prize, to promote research on “lipids and related substances in the fields of Chemistry, Biochemistry, Physiology, and Clinical Medicine”, Munich, Germany, 2004.
- Henrietta Szold Prize for achievements in medical research, Tel-Aviv Municipality, June 2005.
- Doctor Honoris Causa, Complutense University, Madrid, 2006. ECNP (European College of Neuropsychopharmaclogy), Lifetime Achievement Award, Paris, 2006.
- ICRS (International Cannabinoid Research Society) Special Award For lifetime achievements in the cannabinoid field, Cologne, Germany, 2007.
- Israel Chemical Society Prize for excellence in research, Feb. 2009.
- Hebrew University, Medical Faculty Prize for excellence in research, June 2010.
- Eicosanoid Research Foundation Lifetime Achievement Award, Seattle, Washington, September, 2011.
- NIDA Discovery Award, NIH, Bethesda, September 2011.
- Rothschild Prize by Keren Hanadiv (The Rothschild Family Foundation), Jerusalem (in the Knesset) 2012.
- EMET Prize – to be presented by the Prime Minister in November, 2012.

Monday, April 24, 2017

How and Why Cannabis Research is Biased toward Negative Effect

Credit:CSU-Pueblo



The Institute of Cannabis Research (ICR) at Colorado State University-Pueblo is set to start later this week, April 28-30, at the Colorado State University-Pueblo campus.  The conference will open at 5 p.m. on Friday, April 28, with a plenary lecture by Dr. Carl Hart, chair of the Department of Psychology at Columbia University and Dirk Ziff Professor of Psychology in the Departments of Psychology and Psychiatry. He has published numerous scientific articles in neuropsycho-pharmacology and its impact on public policy and drug abuse treatment.


To view the detailed conference schedule and register for the conference, visit the website at www.csupueblo.edu/ICR.

Considering the importance of this opening lecture topic by Dr. Hart and the effect this has had on advancing medical cannabis; there was a very important commentary by Dr. Hart that first appeared in the Dallas News in 2014 that is a great read about this.


“Is America’s scientific research biased to focus on the harmful effects of drugs?”


That was one of the questions at the heart of a congressional hearing this summer seeking to understand more comprehensively the scientific evidence related to marijuana. And it was how Dr. Nora Volkow, director of the National Institute on Drug Abuse, found herself being grilled by Rep. Gerald Connolly, D-Va.


“Dr. Volkow, your testimony seems to completely disregard lots of other data,” he accused.
Volkow and I were the witnesses, along with a representative from the Food and Drug Administration. Connolly was particularly interested in learning why NIDA and the FDA — both part of the U.S. Department of Health and Human Services — supported so little research into the potential medical uses of marijuana. He appeared exasperated by the focus on drugs’ harmful effects, which “impeded the ability to have legitimate research that could benefit human health.”


I have spent nearly 20 years studying the neurophysiological, psychological and behavioral effects of recreational drugs, including marijuana. And over the past decade I, too, have grown tired of hearing scientists detail drug-related negative effects, always warning of the possible neurological and psychiatric dangers users face, while virtually ignoring recreational drugs’ potential medicinal or beneficial effects.


Some are quick to caution that marijuana, for example, is a gateway drug to harder substances but never mention the more than 700,000 people arrested each year mainly for simple possession of the drug, let alone the shameful racial disparities in marijuana arrests. At the state level, black people are two to seven times more likely to be arrested for marijuana than their white counterparts. At the federal level, Hispanics represent two-thirds of the individuals arrested for marijuana violations. This is despite the fact that blacks, Hispanics and whites all use the drug at similar rates.


Few scientists admit publicly what we all know and the data has shown for decades: The overwhelming majority of people who use drugs do so without any problems. For example, different studies show that between 75 and 90 percent will never become addicted.
In fact, the last three occupants of the White House — Bill Clinton, George W. Bush and Barack Obama — all smoked marijuana when they were younger. Obama also admitted to having used cocaine. The point is not to tarnish the reputations of these men — they all served their country. My point is that their drug use did not result in an inevitable downward spiral leading to debauchery and addiction. And the experience of these men is the rule, not the exception. The overwhelming majority of drug users are not derelict addicts.


I often wondered why many scientists continued to emphasize such a limited perspective on the effects produced by recreational drugs, especially in the face of considerable evidence showing their beneficial effects and therapeutic potential.
For example, physicians in multiple countries, including Germany and Switzerland, prescribe heroin as a part of an effective treatment regimen for heroin addiction. Here in the U.S., my colleagues and I have shown that methamphetamine enhances mood and improves cognitive functioning in some domains. Our research also demonstrates that marijuana stimulates appetite in HIV-positive patients, which could be lifesaving for someone suffering from AIDS wasting syndrome.

Mind you, I recognize that some drug advocates overreach when extolling the virtues of, say, marijuana, claiming that the drug is a cure for everything from heartache to cancer. Clearly, many of these claims are exaggerations.
Video: Democracy Now interview with Dr. Hart

This does not, however, mean we should dismiss all claims of a recreational drug’s potential utility. Any informed scientist must know that all drugs — including heroin, cocaine and over-the-counter and prescription medications — can produce both positive and negative effects. They must know that their safe use can be enhanced or diminished depending upon several contextual factors, including the dose taken, the user’s level of tolerance and the setting in which drug use occurs.
In my congressional testimony, I aimed to contextualize marijuana’s effects. Regarding the gateway theory, I agreed that the majority of cocaine and heroin users started out using marijuana first. But I also added a more important detail that is often omitted: The vast majority of pot smokers never go on to use harder drugs. To call marijuana a gateway drug is illogical.


I also added context to marijuana’s addictive potential. During the hearing, it was correctly noted that about 9 percent of pot smokers would become addicted at some point in their life. However, the fact that about 15 percent of alcohol drinkers and a third of tobacco smokers would become addicted over their lifetime was not mentioned until my testimony.


This omission seemed to infuriate Connolly. “For you to only cite the addiction rate with marijuana,” he snapped, “seems to me to be cherry-picking the statistics for a purpose.”
So why do scientists focus almost exclusively on the detrimental effects of drugs when they are, in fact, a minority of effects? Are scientists dishonest? Probably not. They are more likely to be responding to their perceptions of NIDA’s interests.


NIDA funds more than 90 percent of all research on the major recreational drugs. Its mission “is to lead the nation in bringing the power of science to bear on drug abuse and addiction” (emphasis mine). Of course, recreational drugs such as cocaine, heroin and marijuana produce other effects, including positive ones, that have nothing to do with “abuse and addiction,” but that isn’t part of NIDA’s mission.


Scientists seeking research money from NIDA are well aware of this fact. As a result, they emphasize the negative effects of drugs to get their research funded. Upton Sinclair’s famous quote aptly describes this situation: “It is difficult to get a man to understand something when his salary depends upon his not understanding it.” The result is that the majority of information on drugs published in the scientific literature, textbooks and popular press is biased toward the negative aspects of drug use.
It has also helped shape a socio-political environment where certain drugs are deemed evil and any use of these drugs is considered pathological. This, in turn, has provided the fuel for restrictive policies with an unreasonable goal of eliminating illegal drug use at any cost to marginalized groups.


Despite the propensity of researchers to focus primarily on the negative aspects of specific drugs, there has been a movement to liberalize policies that regulate marijuana in the U.S. Twenty-three states and Washington, D.C., now allow patients, with a physician’s authorization, to use marijuana for medical purposes. Colorado and Washington recently became the first states to allow the legal use of the drug by adults for recreational purposes. Yet at the same time, other drugs such as cocaine, heroin and methamphetamine continue to be regulated by draconian policies. These policies have contributed to a horrifying statistic: More than 2 million Americans are behind bars, a greater number than in any other country.


To be clear, I am not advocating the legalization of drugs. (We would need to dramatically increase sound drug education first; people would need to be taught how to use drugs safely, much as we already teach people to drive safely or practice safe sex.) Nor am I advocating the use of illegal drugs.


I am simply asking Americans to consider the broad range of effects produced by illegal drugs so we can devise more rational drug policy — one that neither exaggerates drugs’ harms nor punishes our citizens beyond what’s fair and just.
by Dr. Carl L. Hart is an associate professor of psychology in the departments of psychiatry and psychology at Columbia University and is the author of the recently released book “High Price: A Neuroscientist’s Journey of Self-Discovery That Challenges Everything You Know About Drugs and Society.” Follow him on Twitter at @drcarlhart.



Tuesday, April 18, 2017

4.20 Medical Cannabis Events And Specials

Events & Specials








Recent News from R. Greenleaf
420 So nice We extended it THRICE!
R Greenleaf continued.
***Below pricing does not include tax. We will not be taking pre-orders during this three-day event. Below inventory may vary at each clinic. While supplies last and first come, first served. 100% guarantee does not apply to specially priced products. The winners of the raffle will be notified at close of business on Sunday, April 23rd for ABQ clinics and Saturday, April 22nd for Grants. Winners can claim their prize(s) if and when their units legally allow, as per the rules and regulations of the NM DOH. All monies raised by the raffle is donated to the Patients Assistance Fund at each R. Greenleaf location.***
Below is a breakdown of the raffle and specials we will have from Tuesday 4/18/17-Thursday 4/20/17;
MONDAY-SUNDAY
Raffle!
Tickets for the raffle go on sale on Monday, April 17th. The raffle ends on
Sunday, April 23rd at close of business. One ticket for $1 or five tickets for $4!
Each location is raffling off the following prizes:
4 winners will get a 7-gram jar of medicine!
1 winner will get two of our favorite edibles:
6-pack of gourmet Truffles and a Tristan’s Trail Bar
1 winner will get a pack of all types of BHO:
1/2 gram of Indica, 1/2 gram of Hybrid, 1/2 gram of CBD and 1/2 gram of Sativa
TUESDAY 4/18/17
ALL STRAINS $9.00 per gram
The following edibles are $10 per package (down from $12.50)
Regular Strength Cookies (Indica, CBD and Sativa)
Canna-Crackers (Indica, CBD, Hybrid and Sativa)
Johnny Bars (Hybrid)
The following concentrates are $15 (down from $20.00)
Green Arrow Hash (Indica, CBD and Sativa)
Greenleaf Hash (Indica, CBD and Sativa)
WEDNESDAY 4/19/17
ALL STRAINS $9.00 per gram
The following edibles are $10 per package (down from $12.50)
Peanut Brittle (Indica and Sativa)
ALL Medi-Drops (Regular Strength Indica, Regular Strength CBD, Regular Strength
Hybrid, Regular Strength Sativa, Regular Strength Sugar Free Hybrid and Extra
Strength Hybrid)
Chocolate Bars (Indica, CBD and Sativa)
The following joints are on sale:
Big J $10 (down from $12.50 - Indica, CBD, Hybrid and Sativa)
Little J $5 (down from $7 Indica, CBD and Sativa)
Big J 3-pack $30 (down from $37.50 - Indica and Sativa)
Little J 3-pack $15 (down from $21 - Indica and Sativa)
THURSDAY 4/20/17
All strains $9.00 per gram
ALL BHO is 50% off!
1 gram- $25 (down from $50 - Indica, CBD, Hybrid and Sativa)
1/2 gram- $12.50 (down from $25 - Indica, CBD, Hybrid and Sativa)
The following edibles are $10 per package (usually $12.50)
Regular Strength Brownies (Indica and Sativa)
Regular Strength Cookies (Indica, CBD and Sativa)
Johnny Bar (Hybrid)
Tristan’s Trail Bar (Hybrid)
ALL Medi-Drops (Regular Strength Indica, Regular Strength CBD, Regular
Strength Hybrid, Regular Strength Sativa, Regular Strength Sugar Free Hybrid
and Extra Strength Hybrid)
Canna-Crackers (Indica, CBD, Hybrid and Sativa)
Peanut Brittle (Indica and Sativa)
Chocolate Bars (Indica, CBD and Sativa)


From Verdes Foundation : "On Thursday, April 20th The Verdes Foundation will open early (9 AM – 5:30 PM) to better serve you in celebration of 4/20!
early risers420
Specials Include:
  • EXTENDED EARLY HOURS

  • Both Verdes locations will be open from 9:00 am – 5:30 pm

  • DOUBLE STAMPS

  • Early risers will recieve double stamps on your loyalty card between 9:00 am – Noon
  • $5.00 OFF 4-GRAM CONTAINERS

  • Save $5.00 on your pre-packaged 4-gram flower favorites
  • $1.00 OFF ALL PRE-ROLLS

  • Save $1.00 on all pre-rolls (including SugarPuffs!)
  • FREE PRE-ROLLS W/ YOUR VERDES SHIRT

  • Be sure to wear your Verdes shirt to get your FREE pre-roll"


“From SWOP : Join us for a Celebration of Cannabis next week on Thursday, 4/20.

If you're an early bird, I'm pretty sure that we are the only dispensary in the city that opens at 9am, so drop by before you visit all the other great spots around town.


We have a fun day planned full of food, live music and lots of specials on everything from medicine to accessories.

In addition, we'll be handing out gift bags (while supplies last) with every purchase as well as entering each patient into a raffle for a chance to win one of the glass pieces below. And to celebrate your good fortune, we're throwing in a little SWOP medicine to help you break in your piece.


You don't have to be present to win, but you do have to make a purchase to be entered. The drawing for the winning patients will be held at 4:20pm and the winners, should they not be in attendance, will be notified by phone and/or email.”

SWOP will be open this SATURDAY from 10AM to 2PM, and we are chalk full of deals!
Cannaceutics Inc
“Keep your eyes open next week for our unbeatable 4/20 specials and be sure to drop in on 4/20 to make a purchase. All purchases made on 4/20 will be entered into our drawings for pipes and Cannaceutics swag! Have a great weekend!”  http://www.cannaceutics.org/


At CG : And the 4/20 special…

On Thursday for our 4/20 celebration we will be offering $5 joints all day! No phone orders or holds on 4/20. While supplies last.
Both CG locations will be open our normal business hours of 10am to 7pm for both events.




At Natural Rx ( Facebook Event Here )


At Everest Apothecary: Thursday for 4/20 specials on your favorite strains, edibles and concentrates.
“We'll have a food truck on-site from 12-5 p.m. and keep our doors open until 8 p.m. offering:
-$7 Mid Shelf Grams  -$8 Top Shelf Grams
-$4.20 off Vape Cartridges and Budder Pros Karma Trichs
-$4.20 for all .5G Pre-Rolls and Bhang Nuggets”




“The infamous 4/20 marijuana holiday is quickly approaching and New MexiCann Natural Medicine is the place to be. We will have free giveaways and awesome deals for our patients and if you aren't a patient come talk to our friendly staff about our CBD products! There is something for everyone so stop by any of our four locations.”








Fote Organics 4/20 Celebration: 6-9PM
Come CELEBRATE the healing POWER
of CANNABIS with us on
4/20 in The Paradiso 6-9PM
(warehouse in the back of Fruit of the Earth)
As our thanks to YOU, our patients:
*Live Music - House Reggae Band
*Belly Dance Performances
*FREE CBD Vapor Bar
*FREE Tarot Readings
*FREE Food and Beverages






420 at the Butte
Public Event · Hosted by The Sweet Foundation


Friday ~ April 21st 2017




Saturday - April 22nd - Earth Day


Outdoor Medical Cannabis Cultivation Seminar
· Hosted by Reef Medical Clinic


Complete Listing Of All Dispensaries Here.